Neurologia

Artigos em destaque

Acute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians.
Stroke. 2025 Dec; 57(Dec):549-59. doi: 10.1161/STROKEAHA.125.053504. pii: . Base: PUBMED
- Atualizado em 12/03/2026

Risk of New Indications for Anticoagulants and Thrombolytics in People With Cognitive Impairment: Implications for Anti-Amyloid Therapy.
Neurology. 2026 Jan; 106(Jan):e214489. doi: 10.1212/WNL.0000000000214489. pii: . Base: PUBMED
- Atualizado em 12/03/2026

Development and International Validation of a Novel Imaging-Based Risk Score (IsCHEMiA) for the Prediction of Poststroke Epilepsy.
Neurology. 2026 Jan; 106(Jan):e214486. doi: 10.1212/WNL.0000000000214486. pii: . Base: PUBMED
- Atualizado em 12/03/2026

From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus.
Journal of neurology, neurosurgery, and psychiatry. 2026 Jan; 97(Jan):129-145. doi: 10.1136/jnnp-2025-336076. pii: . Base: PUBMED
- Atualizado em 11/03/2026

An updated overview on clinical and developmental trajectories of developmental and epileptic encephalopathies: From childhood to adulthood.
Seizure. 2026 Jan; 134(Jan):190-197. doi: 10.1016/j.seizure.2025.12.009. pii: S1059-1311(25)00340-1. Base: PUBMED
- Atualizado em 11/02/2026

Clinical practice guidelines for the administration of third-generation anti-seizure medications.
Seizure. 2026 Jan; 134(Jan):13-26. doi: 10.1016/j.seizure.2025.11.002. pii: S1059-1311(25)00296-1. Base: PUBMED
- Atualizado em 11/02/2026

Management of Functional Seizures Practice Guideline Executive Summary: Report of the AAN Guidelines Subcommittee.
Neurology. 2026 Jan; 106(Jan):e214466. doi: 10.1212/WNL.0000000000214466. pii: . Base: PUBMED
- Atualizado em 30/01/2026

News e Reviews

The Role of Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease: A Narrative Review.
Life (Basel, Switzerland). 2026 Feb; 16(Feb):doi: 10.3390/life16030397. pii: 397. Base: PUBMED
- Atualizado em 07/04/2026

2025 Neurocritical Care Updates in Cerebrovascular Disease.
Stroke. 2026 Jan; 57(Jan):205-209. doi: 10.1161/STROKEAHA.125.049903. pii: . Base: PUBMED
- Atualizado em 01/04/2026

Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis.
JAMA neurology. 2026 Feb; 83(Feb):153-160. doi: 10.1001/jamaneurol.2025.5255. pii: . Base: PUBMED
- Atualizado em 20/03/2026

Tuberous sclerosis complex.
Nature reviews. Disease primers. 2026 Mar; 12(Mar):doi: 10.1038/s41572-026-00688-9. pii: 11. Base: PUBMED
- Atualizado em 20/03/2026

A 66-Year-Old Woman Found Unresponsive.
NEJM evidence. 2026 Mar; 5(Mar):EVIDmr2500286. doi: 10.1056/EVIDmr2500286. pii: . Base: PUBMED
- Atualizado em 16/03/2026

Safety of Intracranial Neuromodulation in Drug-Resistant Pediatric and Adult Epilepsy.
Neurology. 2026 Feb; 106(Feb):e214626. doi: 10.1212/WNL.0000000000214626. pii: . Base: PUBMED
- Atualizado em 12/03/2026

Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.
Neurology. 2026 Feb; 106(Feb):e214647. doi: 10.1212/WNL.0000000000214647. pii: e214647. Base: PUBMED
- Atualizado em 12/03/2026

Advances in biomarkers for diagnosis and prognosis of prion diseases.
The Lancet. Neurology. 2026 Feb; 25(Feb):195-205. doi: 10.1016/S1474-4422(25)00406-5. pii: S1474-4422(25)00406-5. Base: PUBMED
- Atualizado em 12/03/2026

Persistent Postural-Perceptual Dizziness: A Practical Approach to Diagnosis and Patient Communication.
European journal of neurology. 2026 Feb; 33(Feb):e70494. doi: 10.1111/ene.70494. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Update on functional vestibular and gait disorders.
Current opinion in neurology. 2026 Feb; 39(Feb):48-53. doi: 10.1097/WCO.0000000000001445. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Faecal microbiota transplant for Parkinson's disease: promises and future directions.
Brain : a journal of neurology. 2026 Jan; 149(Jan):59-70. doi: 10.1093/brain/awaf419. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Targeting brain connectivity in Alzheimer's disease with repurposed drugs.
Ageing research reviews. 2026 Jan; 114(Jan):103001. doi: 10.1016/j.arr.2025.103001. pii: S1568-1637(25)00347-2. Base: PUBMED
- Atualizado em 11/03/2026

Brain connectivity as a new target for Alzheimer's disease therapy?
Brain : a journal of neurology. 2026 Feb; 149(Feb):432-438. doi: 10.1093/brain/awaf404. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Motor learning after stroke: what we've learned and what lies ahead.
Brain : a journal of neurology. 2026 Feb; 149(Feb):386-403. doi: 10.1093/brain/awaf388. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Restless Legs Syndrome: A Review.
JAMA. 2026 Feb; 335(Feb):703-714. doi: 10.1001/jama.2025.23247. pii: . Base: PUBMED
- Atualizado em 02/03/2026

Status Epilepticus.
Emergency medicine clinics of North America. 2026 Feb; 44(Feb):187-202. doi: 10.1016/j.emc.2025.08.011. pii: S0733-8627(25)00066-5. Base: PUBMED
- Atualizado em 27/02/2026

Primary Headache.
Emergency medicine clinics of North America. 2026 Feb; 44(Feb):171-186. doi: 10.1016/j.emc.2025.08.010. pii: S0733-8627(25)00065-3. Base: PUBMED
- Atualizado em 27/02/2026

Diagnosing Serious "Cannot Miss" Causes of Non-traumatic Headache-Thunderclap Headache and Beyond.
Emergency medicine clinics of North America. 2026 Feb; 44(Feb):143-170. doi: 10.1016/j.emc.2025.08.009. pii: S0733-8627(25)00064-1. Base: PUBMED
- Atualizado em 27/02/2026

Cerebral Folate Deficiency, Autism, and the Role of Leucovorin.
The New England journal of medicine. 2026 Feb; 394(Feb):833-835. doi: 10.1056/NEJMp2516268. pii: . Base: PUBMED
- Atualizado em 27/02/2026

Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes: The LAMP Randomized Clinical Trial.
JAMA internal medicine. 2026 Jan; 186(Jan):46-54. doi: 10.1001/jamainternmed.2025.5684. pii: . Base: PUBMED
- Atualizado em 20/02/2026

Cannabis-based medicines for chronic neuropathic pain in adults.
The Cochrane database of systematic reviews. 2026 Jan; 1(Jan):CD012182. doi: 10.1002/14651858.CD012182.pub3. pii: CD012182. Base: PUBMED
- Atualizado em 11/02/2026

Blood and CSF biomarkers for multiple sclerosis: emerging clinical applications.
The Lancet. Neurology. 2025 Dec; 24(Dec):1066-1078. doi: 10.1016/S1474-4422(25)00249-2. pii: S1474-4422(25)00249-2. Base: PUBMED
- Atualizado em 11/02/2026

Muscle MRI Contributes to the Differential Diagnosis Between Distal Myopathies and Distal Hereditary Motor Neuropathies.
European journal of neurology. 2026 Jan; 33(Jan):e70456. doi: 10.1111/ene.70456. pii: e70456. Base: PUBMED
- Atualizado em 11/02/2026

Does Interrater Variation Influence the Classification According to the Diagnostic Criteria for Multiple Sclerosis?
European journal of neurology. 2026 Jan; 33(Jan):e70469. doi: 10.1111/ene.70469. pii: e70469. Base: PUBMED
- Atualizado em 11/02/2026

Therapeutic Use of Cannabis and Cannabinoids: A Review.
JAMA. 2026 Jan; 335(Jan):345-359. doi: 10.1001/jama.2025.19433. pii: . Base: PUBMED
- Atualizado em 10/02/2026

Peripheral Neuropathy: A Review.
JAMA. 2026 Jan; 335(Jan):255-266. doi: 10.1001/jama.2025.19400. pii: . Base: PUBMED
- Atualizado em 04/02/2026

Immunotherapy considerations for distal sensory-predominant and small-fiber peripheral neuropathies.
Handbook of clinical neurology. 2026 ; 214():373-393. doi: 10.1016/B978-0-323-90887-0.00022-5. pii: B978-0-323-90887-0.00022-5. Base: PUBMED
- Atualizado em 30/01/2026

Azathioprine for the treatment of early Parkinson's disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial.
The Lancet. Neurology. 2026 Jan; 25(Jan):39-49. doi: 10.1016/S1474-4422(25)00386-2. pii: S1474-4422(25)00386-2. Base: PUBMED
- Atualizado em 21/01/2026

Efficacy and safety of CGRP monoclonal antibodies for migraine prevention in episodic migraine; a network Meta-analysis.
European journal of clinical pharmacology. 2026 Jan; 82(Jan):27. doi: 10.1007/s00228-025-03934-3. pii: . Base: PUBMED
- Atualizado em 20/01/2026

The gut microbiome, systemic inflammation, and autoimmunity in Parkinson's disease.
The Lancet. Neurology. 2026 Jan; 25(Jan):103-114. doi: 10.1016/S1474-4422(25)00382-5. pii: S1474-4422(25)00382-5. Base: PUBMED
- Atualizado em 09/01/2026

Guideline, consenso e protocolo

Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline.
Neurology. 2023 Dec; 101(Dec):1112-1132. doi: 10.1212/WNL.0000000000207740. pii: . Base : PUBMED
- Atualizado em 18/02/2026

Advancing Disability Equity in Neurology: An AAN Position Statement.
Neurology. 2025 Aug; 105(Aug):e213873. doi: 10.1212/WNL.0000000000213873. pii: . Base : PUBMED
- Atualizado em 26/11/2025

A clinical practice guideline for tuberculous meningitis.
The Lancet. Infectious diseases. 2025 Aug; doi: 10.1016/S1473-3099(25)00364-0. pii: S1473-3099(25)00364-0. Base : PUBMED
- Atualizado em 04/11/2025

Principles for Novel Neurologic Therapeutics: An AAN Position Statement.
Neurology. 2025 Jul; 105(Jul):e213850. doi: 10.1212/WNL.0000000000213850. pii: e213850. Base : PUBMED
- Atualizado em 30/09/2025

Blood-based biomarkers for Alzheimer's disease: positioning document and usage recommendations from the Behavioral Neurology and Dementia Study Group of the Spanish Society of Neurology.
Neurologia. 2025 Jul; doi: 10.1016/j.nrleng.2025.07.004. pii: S2173-5808(25)00066-5. Base : PUBMED
- Atualizado em 30/09/2025

Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2025 Jul; 21(Jul):e70535. doi: 10.1002/alz.70535. pii: . Base : PUBMED
- Atualizado em 30/09/2025

European Academy of Neurology (EAN)/European Federation of Autonomic Societies (EFAS)/International Neuro-Urology Society (INUS) Guidelines for Practising Neurologists on the Assessment and Treatment of Neurogenic Urinary and Sexual Symptoms (NEUROGED Guidelines).
European journal of neurology. 2025 Apr; 32(Apr):e70119. doi: 10.1111/ene.70119. pii: . Base : PUBMED
- Atualizado em 20/08/2025

International Consensus Guidance for the Management of Glucocorticoid Related Complications in Neuromuscular Disease.
Muscle & nerve. 2025 Mar; 71(Mar):309-316. doi: 10.1002/mus.28328. pii: . Base : PUBMED
- Atualizado em 24/06/2025

Consensus Recommendations to Establish Reporting Standards in fMRI of Migraine: A Delphi Study.
Neurology. 2025 Mar; 104(Mar):e210235. doi: 10.1212/WNL.0000000000210235. pii: . Base : PUBMED
- Atualizado em 13/06/2025

IAPRD new consensus classification of myoclonus.
Parkinsonism & related disorders. 2025 Mar; 132(Mar):107216. doi: 10.1016/j.parkreldis.2024.107216. pii: S1353-8020(24)01228-8. Base : PUBMED
- Atualizado em 29/05/2025

High-Grade Subarachnoid Hemorrhage - Beyond Guidelines.
Neurologic clinics. 2025 Feb; 43(Feb):107-126. doi: 10.1016/j.ncl.2024.07.006. pii: S0733-8619(24)00057-4. Base : PUBMED
- Atualizado em 28/04/2025

Prevention of Episodic Migraine Headache Using Pharmacologic Treatments in Outpatient Settings: A Clinical Guideline From the American College of Physicians.
Annals of internal medicine. 2025 Feb; doi: 10.7326/ANNALS-24-01052. pii: . Base : PUBMED
- Atualizado em 13/03/2025

Acceptable performance of blood biomarker tests of amyloid pathology - recommendations from the Global CEO Initiative on Alzheimer's Disease.
Nature reviews. Neurology. 2024 Jul; 20(Jul):426-439. doi: 10.1038/s41582-024-00977-5. pii: . Base : PUBMED
- Atualizado em 28/02/2025

Management of patients with neurological diseases considering post-pandemic coronavirus disease 2019 (COVID-19) related risks and dangers - An updated European Academy of Neurology consensus statement.
European journal of neurology. 2024 Oct; 31(Oct):e16408. doi: 10.1111/ene.16408. pii: e16408. Base : PUBMED
- Atualizado em 21/01/2025

Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.
Neuro-oncology. 2024 Oct; 26(Oct):1742-1780. doi: 10.1093/neuonc/noae082. pii: . Base : PUBMED
- Atualizado em 21/01/2025

International Headache Society global practice recommendations for the acute pharmacological treatment of migraine.
Cephalalgia : an international journal of headache. 2024 Aug; 44(Aug):3331024241252666. doi: 10.1177/03331024241252666. pii: . Base : PUBMED
- Atualizado em 03/01/2025

Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate-Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society.
Neurocritical care. 2024 Jun; 40(Jun):819-844. doi: 10.1007/s12028-023-01907-x. pii: . Base : PUBMED
- Atualizado em 22/08/2024

Management of seizures in patients with primary mitochondrial diseases: consensus statement from the InterERNs Mitochondrial Working Group.
European journal of neurology. 2024 Jul; 31(Jul):e16275. doi: 10.1111/ene.16275. pii: e16275. Base : PUBMED
- Atualizado em 21/08/2024

Expert consensus recommendations for improving and standardising the assessment of patients with generalised myasthenia gravis.
European journal of neurology. 2024 Jul; 31(Jul):e16280. doi: 10.1111/ene.16280. pii: e16280. Base : PUBMED
- Atualizado em 21/08/2024

European Academy of Neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European Reference Network for Neuromuscular Diseases (ERN EURO-NMD).
European journal of neurology. 2024 Jun; 31(Jun):e16264. doi: 10.1111/ene.16264. pii: e16264. Base : PUBMED
- Atualizado em 21/08/2024

AAPM&R consensus guidance on spasticity assessment and management.
PM & R : the journal of injury, function, and rehabilitation. 2024 May; doi: 10.1002/pmrj.13211. pii: . Base : PUBMED
- Atualizado em 12/07/2024

A Systematic Guideline by the ASPN Workgroup on the Evidence, Education, and Treatment Algorithm for Painful Diabetic Neuropathy: SWEET.
Journal of pain research. 2024 ; 17():1461-1501. doi: 10.2147/JPR.S451006. pii: . Base : PUBMED
- Atualizado em 22/04/2024

Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update.
Developmental medicine and child neurology. 2024 Apr; doi: 10.1111/dmcn.15921. pii: . Base : PUBMED
- Atualizado em 22/04/2024

Guidelines of the International Headache Society for Controlled Clinical Trials in Idiopathic Intracranial Hypertension.
Cephalalgia : an international journal of headache. 2023 Aug; 43(Aug):3331024231197118. doi: 10.1177/03331024231197118. pii: . Base : PUBMED
- Atualizado em 19/04/2024

Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments-a consensus article.
The journal of headache and pain. 2023 Sep; 24(Sep):121. doi: 10.1186/s10194-023-01660-8. pii: 121. Base : PUBMED
- Atualizado em 19/04/2024

European Academy of Neurology guidelines on the treatment of cluster headache.
European journal of neurology. 2023 Oct; 30(Oct):2955-2979. doi: 10.1111/ene.15956. pii: . Base : PUBMED
- Atualizado em 19/04/2024

European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain-Barré syndrome.
European journal of neurology. 2023 Dec; 30(Dec):3646-3674. doi: 10.1111/ene.16073. pii: . Base : PUBMED
- Atualizado em 19/04/2024

ENA Clinical Practice Guideline Synopsis: Screening Older Adults for Cognitive Impairment.
Journal of emergency nursing. 2024 Jan; 50(Jan):17-21. doi: 10.1016/j.jen.2023.09.003. pii: S0099-1767(23)00244-1. Base : PUBMED
- Atualizado em 02/02/2024

Latin American consensus recommendations on the risk of infections in people with multiple sclerosis treated with disease modifying drugs.
Multiple sclerosis and related disorders. 2023 Sep; 77(Sep):104840. doi: 10.1016/j.msard.2023.104840. pii: S2211-0348(23)00342-5. Base : PUBMED
- Atualizado em 27/09/2023

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET The Neurodiagnostic Society.
Muscle & nerve. 2023 Aug; 68(Aug):106-121. doi: 10.1002/mus.27850. pii: . Base : PUBMED
- Atualizado em 14/09/2023

Guidelines Update: Guidelines of the International Headache Society for controlled trials of preventive treatment of migraine in children and adolescents, 1st edition - An experience-based update.
Cephalalgia : an international journal of headache. 2023 May; 43(May):3331024231178239. doi: 10.1177/03331024231178239. pii: . Base : PUBMED
- Atualizado em 14/07/2023

Guidelines for the management of trigeminal neuralgia.
Cleveland Clinic journal of medicine. 2023 Jun; 90(Jun):355-362. doi: 10.3949/ccjm.90a.22052. pii: . Base : PUBMED
- Atualizado em 30/06/2023

feed

The Role of Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease: A Narrative Review.
Life (Basel, Switzerland). 2026 Feb; 16(Feb):doi: 10.3390/life16030397. pii: 397. Base: PUBMED
- Atualizado em 07/04/2026

Tuberous sclerosis complex.
Nature reviews. Disease primers. 2026 Mar; 12(Mar):doi: 10.1038/s41572-026-00688-9. pii: 11. Base: PUBMED
- Atualizado em 20/03/2026

A 66-Year-Old Woman Found Unresponsive.
NEJM evidence. 2026 Mar; 5(Mar):EVIDmr2500286. doi: 10.1056/EVIDmr2500286. pii: . Base: PUBMED
- Atualizado em 16/03/2026

Safety of Intracranial Neuromodulation in Drug-Resistant Pediatric and Adult Epilepsy.
Neurology. 2026 Feb; 106(Feb):e214626. doi: 10.1212/WNL.0000000000214626. pii: . Base: PUBMED
- Atualizado em 12/03/2026

Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy.
Neurology. 2026 Feb; 106(Feb):e214647. doi: 10.1212/WNL.0000000000214647. pii: e214647. Base: PUBMED
- Atualizado em 12/03/2026

Update on functional vestibular and gait disorders.
Current opinion in neurology. 2026 Feb; 39(Feb):48-53. doi: 10.1097/WCO.0000000000001445. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Brain connectivity as a new target for Alzheimer's disease therapy?
Brain : a journal of neurology. 2026 Feb; 149(Feb):432-438. doi: 10.1093/brain/awaf404. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Motor learning after stroke: what we've learned and what lies ahead.
Brain : a journal of neurology. 2026 Feb; 149(Feb):386-403. doi: 10.1093/brain/awaf388. pii: . Base: PUBMED
- Atualizado em 11/03/2026

Restless Legs Syndrome: A Review.
JAMA. 2026 Feb; 335(Feb):703-714. doi: 10.1001/jama.2025.23247. pii: . Base: PUBMED
- Atualizado em 02/03/2026

Cerebral Folate Deficiency, Autism, and the Role of Leucovorin.
The New England journal of medicine. 2026 Feb; 394(Feb):833-835. doi: 10.1056/NEJMp2516268. pii: . Base: PUBMED
- Atualizado em 27/02/2026

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